SBME Seminar: Simulation of Kidney Cystogenesis – Dr. James Glazier
Dr. Glazier will illustrate their use in a variety of contexts new and old focusing on epithelial organization, from the simulation of somite formation during development to epithelial homeostasis in the skin and the eye, kidney cystogenesis and developmental toxicology. Dr. Glazier will also discuss the kinds of questions we can answer with Virtual Tissue models to gain scientific insight and for biomedical engineering applications.
Events
Calendar
- This event has passed.
SBME Seminar: Designing extrudable decellularized extracellular matrix materials for bioprinting and tissue engineering – Dr. Matt Kinsella
November 7 @ 2:00 pm - 3:00 pm PST
SBME Seminar: Designing extrudable decellularized extracellular matrix materials for bioprinting and tissue engineering – Dr. Matt Kinsella/p>
Seminar Abstract:
The Kinsella Lab studies the design of extrudable soft biomaterials and biofabrication methods, focusing on developing bioprinted tissue and patient specific organoid models of solid tissues. The lab designs gels from isolated and decellularized extracellular matrix that retain the physical context of the tissue microenvironment. By integrating clinical data (pathohistological, chemosensitivity and patient outcomes, and omics-based methods of patient stratification) during cell selection, we develop samples that allow us to probe into the mechanistic understanding of how tissue microenvironments and stromal-induced dynamic reciprocity influence tissue properties during development, tissue homeostasis, or disease progression. We are currently investigating patient-specific cancer models to understand the influence of ECM mechanobiology on the cytotoxic activity of tumor-infiltrating lymphocytes (TILs) and other potential therapeutic immune cells (iNK, CAR-T) whose clinical translational is currently challenged when presented with solid tissues.
Dr. Matt Kinsella Biography:
Matt is an associate professor in the Department of Bioengineering at McGill, where he started his faculty career in 2012 as the founding member of the department. In addition to his appointment in engineering, he is also a member of the McGill Regenerative Medicine Network (MRM), Artificial Cells & Organs Research Centre, and the Goodman Cancer Institute (GCI). Before joining the faculty at McGill University, Matt was an American Cancer Society Postdoctoral Fellow at the University of California, San Diego, and the Sanford Burnham Medical Research Institute. He received his Ph.D. in Biomedical Engineering from the Weldon School of Biomedical Engineering at Purdue University in 2007. His research team designs and synthesizes materials for bioprinting, tissue engineering, and developing models to study microenvironment dynamics during disease or development.
Location:
LSC 1003