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SBME Propels: The Commercialization Workshop Series: Workshop 1: From Research to Market – An Introduction

SBME Research Seminar - Dr. Hannah Carter

Immune Checkpoint Blockade (ICB) has revolutionized cancer treatment, however mechanisms determining patient response remain poorly understood. We used machine learning to predict ICB response from germline and somatic biomarkers and studied feature usage by the learned model to uncover putative mechanisms driving superior outcomes. Patients with higher T follicular helper infiltrates were robust to defects in the class-I Major Histocompatibility Complex (MHC-I). Further investigation uncovered different ICB responses in MHC-I versus MHC-II neoantigen reliant tumors across patients. Despite similar response rates, MHC-II reliant responses were associated with significantly longer durable clinical benefit (Discovery: Median OS=63.6 vs. 34.5 months P=0.0074; Validation: Median OS=37.5 vs. 33.1 months, P=0.040). Characteristics of the tumor immune microenvironment reflected MHC neoantigen reliance, and analysis of immune checkpoints revealed LAG3 as a potential target in MHC-II but not MHC-I reliant responses. This study highlights the value of interpretable machine learning models in elucidating the biological basis of therapy responses.

SBME Research Seminar: Using interpretable machine learning to study the genetic determinants of immunotherapy response – Dr. Hannah Carter

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SBME Propels: The Commercialization Workshop Series: Workshop 1: From Research to Market – An Introduction

November 7, 2024 @ 12:00 pm - 1:00 pm PST

SBME Propels: The Commercialization Workshop Series: Workshop 1: From Research to Market – An Introduction

 
 
 
 
 
In this interactive workshop, participants will explore the critical first steps in translating research into a viable product or solution. We will focus on identifying and refining research to address unmet needs in the market, with an emphasis on medical, scientific, and technological applications. Through a combination of lectures, case studies, and practical exercises, attendees will learn how to define their problem, ideate solutions, and build a compelling value proposition.

The series consists of four workshops, each building on the previous one to equip participants with essential skills and insights. The workshops will cover key aspects of the commercialization process, including identifying market needs, protecting intellectual property, securing funding, and refining research solutions for market entry. The series culminates in a final showcase, where participants present their projects to a panel of industry experts, venture capitalists, and funding representatives.

Learn more: SBME Propels
Register for the workshop

Location:
Graham Lee Innovation Centre (lower floor of the Robert H. Lee Alumni Centre)

Details

Date:
November 7, 2024
Time:
12:00 pm - 1:00 pm PST
Event Categories:
,

Organizer

Danielle Walker
Email
partnerships@sbme.ubc.ca
View Organizer Website

Venue

UBC