SBME Seminar: Simulation of Kidney Cystogenesis – Dr. James Glazier
Dr. Glazier will illustrate their use in a variety of contexts new and old focusing on epithelial organization, from the simulation of somite formation during development to epithelial homeostasis in the skin and the eye, kidney cystogenesis and developmental toxicology. Dr. Glazier will also discuss the kinds of questions we can answer with Virtual Tissue models to gain scientific insight and for biomedical engineering applications.
Events
Calendar
- This event has passed.
SBME Special Seminar: Advancing Human Regenerative Medicine via Modelling Embryogenesis – Dr. Mo Ebrahimkhani
November 21 @ 3:00 pm - 4:00 pm PST
SBME Seminar: Simulation of Kidney Cystogenesis – Dr. James Glazier
Seminar Abstract:
The implantation of human embryos initiates a critical developmental phase encompassing pivotal events such as the formation of the body axis and germ layers, hematopoietic system emergence, and subsequent formation of organ buds. Studying early post-implantation stages of human embryogenesis faces technical and ethical hurdles and is historically known as the black box of human development. We introduce heX-embryoids, a genetically inducible “model” showcasing self-organizing post-implantation cellular programs. They exhibit the formation of events like the development of the amniotic cavity, the generation of tissue progenitor cells, and the multilineage yolk sac morphogenesis with distinct waves of blood cells. I will discuss our recent studies on using this model for regenerative medicine and its implications for decoding human diseases.
Location:
LSC 1003 (LT3)