SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das
The discovery and design of biologically important RNA molecules has lagged behind proteins, in part due to the general difficulty of three-dimensional RNA structural characterization. What are the prospects for an ‘AlphaFold moment’ for RNA? I’ll describe some recent progress in modeling RNA structure from old-fashioned and new machine learning, cryoelectron microscopy, and current and upcoming internet-scale competitions hosted on the Eterna, Kaggle, and CASP platforms.
SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das
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SBME Special Seminar: Advancing Human Regenerative Medicine via Modelling Embryogenesis – Dr. Mo Ebrahimkhani
November 21, 2024 @ 3:00 pm - 4:00 pm PST
SBME Seminar: Simulation of Kidney Cystogenesis – Dr. James Glazier
Seminar Abstract:
The implantation of human embryos initiates a critical developmental phase encompassing pivotal events such as the formation of the body axis and germ layers, hematopoietic system emergence, and subsequent formation of organ buds. Studying early post-implantation stages of human embryogenesis faces technical and ethical hurdles and is historically known as the black box of human development. We introduce heX-embryoids, a genetically inducible “model” showcasing self-organizing post-implantation cellular programs. They exhibit the formation of events like the development of the amniotic cavity, the generation of tissue progenitor cells, and the multilineage yolk sac morphogenesis with distinct waves of blood cells. I will discuss our recent studies on using this model for regenerative medicine and its implications for decoding human diseases.
Location:
LSC 1003 (LT3)