SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das
The discovery and design of biologically important RNA molecules has lagged behind proteins, in part due to the general difficulty of three-dimensional RNA structural characterization. What are the prospects for an ‘AlphaFold moment’ for RNA? I’ll describe some recent progress in modeling RNA structure from old-fashioned and new machine learning, cryoelectron microscopy, and current and upcoming internet-scale competitions hosted on the Eterna, Kaggle, and CASP platforms.
SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das
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SBME Seminar: Reconstitution of mammalian life cycle in vitro – Dr. Nobuhiko Hamazaki
April 19, 2024 @ 10:00 am - 11:00 am PDT
SBME Seminar: Reconstitution of mammalian life cycle in vitro – Dr. Nobuhiko Hamazaki
Seminar Abstract:
Mammalian development is still enigmatic processes as it undergoes all the process in mother’s uterus. Historically, simply taking any part of the processes out from the uterus to dish has brought tremendous findings. For example, in vitro fertilization and the subsequent culture of embryos up to the blastocyst stage have given us the opportunity to monitor, manipulate, and investigate post-fertilization development. Here we will introduce two in vitro model systems: directly induced oocyte-like cells (DIOLs) and human advanced gastruloid model, which recapitulates mouse oocyte development and human post-gastrulation development, respectively, entirely in vitro. These systems provide robust and scalable platforms for investigating the mechanisms underlying mammalian life cycles, as well as failures in these processes, including infertility and developmental diseases.
Dr. Nobuhiko Hamazaki’s Biography
I did a 1st Postdoc in Japan in Katsuhiko Hayashi lab and did 2nd Postdoc in Seattle in Jay Shendure lab. Recently I started my own lab at the University of Washington to pursue the fundamental biological questions by integrating genomics tools to stem cell models.
Location:
LSC 1003 (LT3)