SBME Research Seminar - Dr. Hannah Carter
Immune Checkpoint Blockade (ICB) has revolutionized cancer treatment, however mechanisms determining patient response remain poorly understood. We used machine learning to predict ICB response from germline and somatic biomarkers and studied feature usage by the learned model to uncover putative mechanisms driving superior outcomes. Patients with higher T follicular helper infiltrates were robust to defects in the class-I Major Histocompatibility Complex (MHC-I). Further investigation uncovered different ICB responses in MHC-I versus MHC-II neoantigen reliant tumors across patients. Despite similar response rates, MHC-II reliant responses were associated with significantly longer durable clinical benefit (Discovery: Median OS=63.6 vs. 34.5 months P=0.0074; Validation: Median OS=37.5 vs. 33.1 months, P=0.040). Characteristics of the tumor immune microenvironment reflected MHC neoantigen reliance, and analysis of immune checkpoints revealed LAG3 as a potential target in MHC-II but not MHC-I reliant responses. This study highlights the value of interpretable machine learning models in elucidating the biological basis of therapy responses.
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SBME Seminar: Exploring lung tissue stem cells through developmental biology and organoids – Dr. Mitsuru Morimoto
April 25, 2024 @ 11:00 am - 12:00 pm PDT
SBME Seminar: Exploring lung tissue stem cells through developmental biology and organoids
Seminar Abstract:
The lung tissue harbors various types of epithelial tissue stem cells that plays crucial roles in tissue homeostasis and regeneration from acute damage caused by inhaled chemical particles as well as virus/bacterial infections. Because of such important roles, functional disorder of tissue stem cells relates to respiratory diseases. In this seminar, I would like to introduce two our current findings regarding lung tissue stem cells; (1) conserved Tgfb-Id axis in basal stem cells in development and tissue regeneration, (2) finding new lung stem cell population by combining organoid live imaging, single-cell morphometry and single-cell sequencing.
Dr. Mitsuru Morimoto’s Biography
Mitsuru Morimoto is the team leader of the Lab for Lung Development and Regeneration at RIKEN BDR, concurrently holding visiting professorships at Kyoto University and Kobe University. His research focus on elucidating conserved molecular mechanisms involved in lung tissue development and regeneration, particularly investigating dynamics of individual cells in forming complex multicellular systems. Additionally, he is engaged in the development of protocols for inducing respiratory mesenchymal cells from ES/iPS cells.
Location:
LSC 1002 (LT2)