Translating single-cell microfluidics from academic lab to global biotech impact
We’re honoured to welcome Dr Carl Hansen, CEO & Co-Founder of AbCellera, for a special research seminar
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SBME Seminar: Challenges toward ultrahigh-speed proteomics with high-sensitivity, high-depth and high-robustness – Dr. Yasushi Ishihama
July 8, 2024 @ 2:30 pm - 3:30 pm PDT
SBME Seminar: Challenges toward ultrahigh-speed proteomics with high-sensitivity, high-depth and high-robustness – Dr. Yasushi Ishihama
Seminar Abstract:
Understanding proteins and protein complexes as molecules responsible for biological functions is an essential step in understanding biological homeostasis and the diseases that result from its disruption. Although proteome sequencers based on LC/MS/MS as a core technology have been rapidly developed, they have not yet fully met the expectations of the research community. We have focused on accelerating the LC/MS/MS sequencing technology and have investigated various methods to complete proteome sequencing in about 1 minute. By optimizing various parameters under capillary LC flow rates, we have succeeded in achieving the protein identification number of >3000 from 100 ng of HeLa lysates in 1000 samples per day. In this talk, I will introduce our practical and robust high-speed proteome sequencer and report on applications that take advantage of its ultra-high speed.
Location:
LSC 1003 LT3