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SBME Seminar: Challenges toward ultrahigh-speed proteomics with high-sensitivity, high-depth and high-robustness – Dr. Yasushi Ishihama

SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das

The discovery and design of biologically important RNA molecules has lagged behind proteins, in part due to the general difficulty of three-dimensional RNA structural characterization. What are the prospects for an ‘AlphaFold moment’ for RNA? I’ll describe some recent progress in modeling RNA structure from old-fashioned and new machine learning, cryoelectron microscopy, and current and upcoming internet-scale competitions hosted on the Eterna, Kaggle, and CASP platforms.

SBME Research Seminar: The RNA folding problem remains open – Dr. Rhiju Das

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SBME Seminar: Challenges toward ultrahigh-speed proteomics with high-sensitivity, high-depth and high-robustness – Dr. Yasushi Ishihama

July 8, 2024 @ 2:30 pm - 3:30 pm PDT

SBME Seminar: Challenges toward ultrahigh-speed proteomics with high-sensitivity, high-depth and high-robustness – Dr. Yasushi Ishihama

 
Seminar Abstract:
Understanding proteins and protein complexes as molecules responsible for biological functions is an essential step in understanding biological homeostasis and the diseases that result from its disruption. Although proteome sequencers based on LC/MS/MS as a core technology have been rapidly developed, they have not yet fully met the expectations of the research community. We have focused on accelerating the LC/MS/MS sequencing technology and have investigated various methods to complete proteome sequencing in about 1 minute. By optimizing various parameters under capillary LC flow rates, we have succeeded in achieving the protein identification number of >3000 from 100 ng of HeLa lysates in 1000 samples per day. In this talk, I will introduce our practical and robust high-speed proteome sequencer and report on applications that take advantage of its ultra-high speed.
 
Dr. Yasushi Ishihama headshot
 
Location:
LSC 1003 LT3

Details

Date:
July 8, 2024
Time:
2:30 pm - 3:30 pm PDT
Event Categories:
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Organizer

SBME
Email
reception@sbme.ubc.ca
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Venue

UBC Life Sciences Intitute
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3 Canada
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