Gene regulatory mechanisms in the launch process of T cell development
We’re honoured to welcome Dr. Ellen Rothenberg, Edward B. Lewis Professor of Biology at Caltech, for a special research seminar.
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Research Seminar: Beyond the Transcriptome: Proteome-Wide Overexpression Screening for Clinical Insight – Dr. Dae-Kyum Kim
Location:
Lecture Theatre B1001, Gordon B. Shrum Building – 6088 University Boulevard, Vancouver BC
This talk introduces BOGO, a novel proteome-wide gene overexpression platform designed to proactively identify cancer vulnerabilities that are often missed by traditional patient-data-driven methods. By systematically screening the entire human ORFeome in an isogenic cell line, this approach successfully uncovered clinically relevant genes that regulate cell proliferation and confer resistance to a wide range of chemotherapeutic drugs. The results validate this platform as a powerful tool for discovering novel therapeutic targets and developing rational combination therapies in personalized oncology and other complex diseases.