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Propels: Ethics in Health Research

SBME Research Seminar - Dr. Hannah Carter

Immune Checkpoint Blockade (ICB) has revolutionized cancer treatment, however mechanisms determining patient response remain poorly understood. We used machine learning to predict ICB response from germline and somatic biomarkers and studied feature usage by the learned model to uncover putative mechanisms driving superior outcomes. Patients with higher T follicular helper infiltrates were robust to defects in the class-I Major Histocompatibility Complex (MHC-I). Further investigation uncovered different ICB responses in MHC-I versus MHC-II neoantigen reliant tumors across patients. Despite similar response rates, MHC-II reliant responses were associated with significantly longer durable clinical benefit (Discovery: Median OS=63.6 vs. 34.5 months P=0.0074; Validation: Median OS=37.5 vs. 33.1 months, P=0.040). Characteristics of the tumor immune microenvironment reflected MHC neoantigen reliance, and analysis of immune checkpoints revealed LAG3 as a potential target in MHC-II but not MHC-I reliant responses. This study highlights the value of interpretable machine learning models in elucidating the biological basis of therapy responses.

SBME Research Seminar: Using interpretable machine learning to study the genetic determinants of immunotherapy response – Dr. Hannah Carter

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Propels: Ethics in Health Research

November 20, 2024 @ 12:00 pm - 1:00 pm PST

Propels: Ethics in Health Research

Navigating the ethical considerations for health research, including AI applications. Topics: obtaining ethical approvals (REB), patient safety, data privacy, responsible AI practices, and broader ethical considerations in biomedical and pharmaceutical research.
 
 
 
 
 
Registration is required.

 
 
Speaker

• Holly Longstaff, Director of Research Integration and Innovation, Provincial Health Services Authority (PHSA)

 
Location:
Virtual
 

Details

Date:
November 20, 2024
Time:
12:00 pm - 1:00 pm PST
Event Categories:
, ,

Organizer

Danielle Walker
Email
partnerships@sbme.ubc.ca
View Organizer Website

Venue

Virtual