SBME
Events

Advanced Genomics and Genome Engineering Workshop

SBME Research Seminar - Dr. Hannah Carter

Immune Checkpoint Blockade (ICB) has revolutionized cancer treatment, however mechanisms determining patient response remain poorly understood. We used machine learning to predict ICB response from germline and somatic biomarkers and studied feature usage by the learned model to uncover putative mechanisms driving superior outcomes. Patients with higher T follicular helper infiltrates were robust to defects in the class-I Major Histocompatibility Complex (MHC-I). Further investigation uncovered different ICB responses in MHC-I versus MHC-II neoantigen reliant tumors across patients. Despite similar response rates, MHC-II reliant responses were associated with significantly longer durable clinical benefit (Discovery: Median OS=63.6 vs. 34.5 months P=0.0074; Validation: Median OS=37.5 vs. 33.1 months, P=0.040). Characteristics of the tumor immune microenvironment reflected MHC neoantigen reliance, and analysis of immune checkpoints revealed LAG3 as a potential target in MHC-II but not MHC-I reliant responses. This study highlights the value of interpretable machine learning models in elucidating the biological basis of therapy responses.

SBME Research Seminar: Using interpretable machine learning to study the genetic determinants of immunotherapy response – Dr. Hannah Carter

Events
Calendar

Loading Events

« All Events

  • This event has passed.

Advanced Genomics and Genome Engineering Workshop

September 8, 2023 @ 10:30 am - 4:30 pm PDT

Join our Advanced Genomics and Genome Engineering workshop for a series of talks from visiting professors Mikiko Siomi from the University of Tokyo, Haruhiko Siomi from Keio University, Hiroshi Ochiai from Kyushu University, and our very own UBC staff and researchers.
 
 
 
 
This session will focus on Advanced Genomics and Genome Engineering research. Specifically, there will be a series of talks presented on a variety of different topics. See the list below for the talk titles and presenters:

    • “Transcriptional memory and dynamics in embryonic stem cells” – Sheila Teves

    • “Embryonic development requires transposon expression” – Haruhiko Siomi

    • “Evolutionary trajectory of segmental duplications in vertebrate genomes” – Yusuke Kijima

    • “Evaluation and optimization of sequence-based gene regulatory deep learning models” – Rafi Abdul Muntakim

    • “The evolution, evolvability and engineering of gene regulatory DNA” – Carl de Boer

    • “Chromatin structure and transcriptional dynamics: insights from chromatin tracing” – Hiroshi Ochiai

    • “Isolating cells that have predicted future states” – Nozomu Yachie

    • “Evolution and divergence of eukaryotic transcription factors” – Hazel Cui

    • “piRNA in transposon silencing in the germline” – Mikiko Siomi

Details

Date:
September 8, 2023
Time:
10:30 am - 4:30 pm PDT

Organizer

SBME
Email
reception@sbme.ubc.ca
View Organizer Website

Venue

UBC