Professor, Dept of Medical Genetics and SBME;
Director & Distinguished Scientist, Terry Fox Laboratory


Research Theme:

Research Interests:

stem cells & control of normal development and oncognesis, heart and liver development, genomics, transcription factors, epigenetics, genome editing, cell lineage tracing, differentiation


Dr. Hoodless completed her PhD at Queen’s University at Kingston Ontario, followed by postdoctoral work at Rockefeller University in New York and The Hospital for Sick Children in Toronto. Dr. Hoodless joined the Department of Medical Genetics at UBC in 2000 and became a founding member of the School for Biomedical Engineering in 2017. She also contributes as a member of the UBC Research Excellence Cluster BC Regenerative Medicine. Dr. Hoodless’ early, breakthrough work on TGFβ signal transduction uncovered the mechanisms of Smad-mediated signalling. Her current research combines her interests in gene regulation, signal transduction and embryology. Her work uses genomic technologies to understand how genes regulate organ identity, and specifically how transcription and epigenetic factors drive liver and heart valve formation. We use genetic modification in two model systems to study differentiation, the mouse embryo and human pluripotent stem cells. Dr. Hoodless currently serves as Director and Distinguished Scientist at the Terry Fox Laboratory located at the BC Cancer Research Institute.