Director, Life Sciences Institute
Professor, UBC Department of Medical Genetics


Research Theme:

Research Interests:

Genetic editing, human iPS cell models of disease, organoid cultures, blood vessel engineering, T cell biology, glycoproteomics in cancer, haploid stem cells


The goal of the Penninger Lab is to develop new and effective treatments for diseases by uncovering the fundamental biological principles underlying development and disease. To accomplish these goals, the lab develops and deploys a broad range of in vitro and in vivo tools tha reveal the fundamental mechanisms involved in human disease. These approaches include genetic editing in vitro and in vivo, human-induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, mouse nad human organoid cultures, and genetically engineered mice. The lab’s multidisciplinary techniques enable them to model and study the complexity of diseases.