Professor, Dept of Cellular & Physiological Sciences and SBME
genes and genetic products involved in regulating tissue architecture in breast and ovarian carcinoma progression
Dr. Roskelley laboratory is focused on understanding the genes and their products involved in regulating tissue architecture in breast and ovarian carcinoma progression. They have developed specialized, 3-dimensional models that allow for the recapitulation of normal epithelial tissue architecture outside the body in a tissue culture dish.
They are now modulating the expression and function of cell adhesion molecules in these cultures to determine how architectural disruption allows epithelial cells to break away from the original tumor and begin invading surrounding tissues. The Roskelley group is also determining the specific molecules that are involved in regulating this migratory switch in breast and ovarian tumor cells.