Research Seminar with Dr. Matthew Chang – Engineering Microbes for Dynamic Host-Microbiome Modulation

Meeting ID: 693 4383 4453
Passcode: 608808

Location: Lecture Theatre B1009, Gordon B. Shrum Building (SHRM)

Recent advances in understanding the composition and function of the human microbiota have highlighted its critical roles in health and disease, spurring the development of targeted interventions. At the same time, synthetic biology has enabled the creation of programmable genetic circuits and the reprogramming of living cells, paving the way for next-generation microbiota-based therapies. In this presentation, I will share our latest progress in transforming commensal microbes into multifunctional platforms with clinically relevant capabilities. In particular, I will highlight efforts to develop these microbes as autonomous therapeutic agents that operate in vivo to modulate the microbiome and target infections, metabolic disorders, and cancers. Our research establishes a strong foundation for rewiring host-microbiome interactions and underscores the promise of microbial engineering as a new class of clinical intervention. http://SynBioLab.org/

Dr. Matthew Chang’s Biography:

Matthew Chang is Provost’s Chair Professor of Biochemistry at the Yong Loo Lin School of Medicine, National University of Singapore, and Executive Director of Singapore’s National Centre for Engineering Biology. He directs the Singapore Consortium for Synthetic Biology, the Wilmar-NUS Corporate Laboratory, and NUS Synthetic Biology for Clinical and Technological Innovation. His research focuses on engineering autonomous, programmable cells for biomedicine and biomanufacturing. He co-founded the Global Biofoundry Alliance and the Asian Synthetic Biology Association, and co-chairs the World Economic Forum’s Global Future Council on Generative Biology.